Description: Anti-GABAA Receptor α1 Antibody | 06-868 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: This antibody recognizes the topographical domain of GABAA Receptor α1. View All» Molecular Weight: ~51 kDa observed View All» Epitope: Topological domain. View All» Immunogen: KLH-conjugated linear peptide corresponding to the topological domain of rat GABAA Receptor α1. View All» Background Information: The neurotransmitter GABA (gamma-aminobutyric acid) binds to specific transmembrane receptors in the plasma membrane of both pre- and postsynaptic neurons. Three general classes of GABA receptors are known: GABAA and GABAC (ionotropic) receptors and GABAB (metabotropic) receptors. The GABAA (gamma-Aminobutyric Acid type A) receptor is a multiprotein complex that acts as a ligand-gated chloride channel. These receptors are hetero-oligomers, for which 6 subunits are currently known (a, b, g, d, e and r). There are at least 6 different isoforms of the alpha subunit, and receptor subunit expression varies during development. Increased alpha1 subunit assembly in postsynaptic receptors of cerebellar inhibitory synapses is responsible for the fast inhibitory synaptic currents observed during postnatal development. Additionally, alpha1-containing GABAA receptors are important in regulating the reinforcing properties of alcohol, and expression of the alpha1 subunit increases upon chronic exposure to alcohol, making it a potential therapeutic target for alcohol dependency. View All» Species Reactivity:

Rat

Mouse View All» Species Reactivity Note: Demonstrated to react with Rat and Mouse. Other homologies: Human (94% sequence homology). View All» Application Notes: Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected GABAA Receptor α1 in rat hippocampus tissue.Immunoprecipitation Analysis: 5 µL from a representative lot immunoprecipitated GABAA Receptor α1 in rat brain microsomal preparation RIPA lysate. View All» Control: Rat Brain Microsomal Preparation Tissue Lysate. View All» Quality Assurance: Evaluated by Western Blot in rat brain microsomal preparation tissue lysate.Western Blot Analysis: A 1:10,000 dilution of this antibody detected GABAA Receptor α1 in 10 µg of rat brain microsomal preparation tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P62813 View All» Entrez Gene Number: Np_899155 View All» Gene Symbol:

Gabra1

Gabra-1

GABA

EJM View All» Alternate Names:

Gamma-Amino Butyric Acid Receptor Subunit Alpha-1

Gaba(A) Receptor Subunit Alpha-1

GABA(A) receptor subunit alpha-1

gamma-aminobutyric acid (GABA) A receptor, alpha 1

gamma-aminobutyric acid A receptor, alpha 1 View All» Key Applications:

Western Blotting

Immunohistochemistry (Paraffin)

Immunoprecipitation View All» Entrez Gene Summary: Subunit of GABAA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain. View All» UniProt Summary: FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.SUBUNIT STRUCTURE: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Binds UBQLN1. Interacts with TRAK1.SUBCELLULAR LOCATION: Cell junction > synapse > postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. View All» Brand Family: Upstate View All» Product Name: Anti-GABAA Receptor α1 Antibody | 06-868 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»

产品货号：06-868

品牌：Merck Millipore

规格：200UL

目录价：￥6281.00

市场价格：￥5338.85

平台价格：￥5024.80